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Gastrinoma is a type of neuroendocrine tumor that primarily affects the pancreas or duodenum (the first part of the small intestine). These tumors produce excessive amounts of gastrin, a hormone that stimulates the stomach to produce acid. This overproduction of gastrin leads to increased stomach acid secretion, resulting in a condition known as Zollinger-Ellison syndrome (ZES). ZES causes recurrent peptic ulcers in the stomach and duodenum, as well as gastroesophageal reflux disease (GERD).